{"id":918,"date":"2004-07-13T03:15:07","date_gmt":"2004-07-13T03:15:07","guid":{"rendered":"http:\/\/agnieszkabiskup.com\/?p=918"},"modified":"2011-05-01T18:32:43","modified_gmt":"2011-05-01T23:32:43","slug":"genetics-gene-implicated-in-aging-and-fertility","status":"publish","type":"post","link":"https:\/\/agnieszkabiskup.com\/?p=918","title":{"rendered":"genetics: gene implicated in aging and fertility"},"content":{"rendered":"<p><span style=\"color: #000000;\">Mayo Clinic researchers have discovered a gene  that plays a role in regulating aging and fertility in mice, which may  lead to a better understanding of age-related disorders in humans. In  the July issue of <em>Nature Genetics,<\/em> Jan van Deursen and colleagues report  that a gene called BubR1 regulates a protein that controls physical  aging in mice. The researchers discovered that mice genetically  engineered to lack normal amounts of the BubR1 protein aged prematurely,  living only a fifth as long as normal mice. BubR1 protein levels in  normal mice also declined as they got older, suggesting that a lack of  the protein could be responsible for some of the physiological effects  of aging. Mice with low amounts of the protein developed cataracts  similar to those seen in people over age 65. The mice were also  infertile, their reproductive cells having chromosomal abnormalities.  For humans, abnormal numbers of chromosomes in sex cells are also a  hallmark of reproductive aging, a cause of Down syndrome and  stillbirths. &#8220;It seems reasonable to assume that this protein may  contribute to age-related infertility and certain birth defects in  humans,&#8221; van Deursen stated in a press release. It is hoped the finding  will lead to better treatments of these disorders. <\/span><\/p>\n<h6><em>This news brief appeared in the Discoveries column of the <\/em>Boston Globe&#8217;s<em> Health\/Science section on 7\/13\/2004.<\/em><\/h6>\n","protected":false},"excerpt":{"rendered":"<p>Mayo Clinic researchers have discovered a gene that plays a role in regulating aging and fertility in mice, which may lead to a better understanding of age-related disorders in humans. In the July issue of Nature Genetics, Jan van Deursen &hellip; <a href=\"https:\/\/agnieszkabiskup.com\/?p=918\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13,4],"tags":[],"class_list":["post-918","post","type-post","status-publish","format-standard","hentry","category-boston-globe-3","category-news-briefs"],"_links":{"self":[{"href":"https:\/\/agnieszkabiskup.com\/index.php?rest_route=\/wp\/v2\/posts\/918","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/agnieszkabiskup.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/agnieszkabiskup.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/agnieszkabiskup.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/agnieszkabiskup.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=918"}],"version-history":[{"count":2,"href":"https:\/\/agnieszkabiskup.com\/index.php?rest_route=\/wp\/v2\/posts\/918\/revisions"}],"predecessor-version":[{"id":1042,"href":"https:\/\/agnieszkabiskup.com\/index.php?rest_route=\/wp\/v2\/posts\/918\/revisions\/1042"}],"wp:attachment":[{"href":"https:\/\/agnieszkabiskup.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=918"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/agnieszkabiskup.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=918"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/agnieszkabiskup.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=918"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}