{"id":190,"date":"2003-12-30T02:03:00","date_gmt":"2003-12-30T02:03:00","guid":{"rendered":"http:\/\/agnieszkabiskup.com\/?p=190"},"modified":"2011-05-01T18:33:27","modified_gmt":"2011-05-01T23:33:27","slug":"cholesterol-free-mouse","status":"publish","type":"post","link":"https:\/\/agnieszkabiskup.com\/?p=190","title":{"rendered":"cholesterol-free mouse"},"content":{"rendered":"<p><span style=\"color: #000000;\">With the glut of cholesterol-free everything on  the market, now comes the cholesterol-free mouse, reports an  international team of researchers in the Dec. 19 <em>Science.<\/em> Cholesterol,  despite being notorious for clogging arteries and contributing to heart  disease and strokes, has long been considered integral for survival. The  fat-like substance plays many roles in the body, being vital for  cellular signaling and the formation of hormones, and it is an essential  structural building block of cells and their membranes. But now  researchers from Quark Biotech Inc. in the United States, the Karolinska  Institute in Sweden, and the Sackler School of Medicine in Israel have  created mice with a genetic mutation that disrupts the manufacture of  cholesterol in their bodies, replacing it with a substance called  desmosterol. The cholesterol-free mice were 25 percent smaller than  normal when born and both males and females were infertile, but were  otherwise relatively healthy. In humans, a similar genetic deficiency  causes severe abnormalities. &#8220;We were surprised by the fact that a mouse  lacking cholesterol can survive and develop into adulthood with little  effect,&#8221; stated study author Elena Feinstein of Quark Biotech. <\/span><\/p>\n<h6><em>This news brief appeared in the Random Data column of the <\/em>Boston Globe&#8217;s<em> Health\/Science section on 12\/30\/2003.<\/em><\/h6>\n","protected":false},"excerpt":{"rendered":"<p>With the glut of cholesterol-free everything on the market, now comes the cholesterol-free mouse, reports an international team of researchers in the Dec. 19 Science. Cholesterol, despite being notorious for clogging arteries and contributing to heart disease and strokes, has &hellip; <a href=\"https:\/\/agnieszkabiskup.com\/?p=190\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13,4],"tags":[],"class_list":["post-190","post","type-post","status-publish","format-standard","hentry","category-boston-globe-3","category-news-briefs"],"_links":{"self":[{"href":"https:\/\/agnieszkabiskup.com\/index.php?rest_route=\/wp\/v2\/posts\/190","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/agnieszkabiskup.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/agnieszkabiskup.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/agnieszkabiskup.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/agnieszkabiskup.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=190"}],"version-history":[{"count":7,"href":"https:\/\/agnieszkabiskup.com\/index.php?rest_route=\/wp\/v2\/posts\/190\/revisions"}],"predecessor-version":[{"id":1097,"href":"https:\/\/agnieszkabiskup.com\/index.php?rest_route=\/wp\/v2\/posts\/190\/revisions\/1097"}],"wp:attachment":[{"href":"https:\/\/agnieszkabiskup.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=190"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/agnieszkabiskup.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=190"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/agnieszkabiskup.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=190"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}